Falmouth is an all-weather all tide large natural harbour, and it has numerous destinations within the harbour. Helford River is not far outside which can become a cruise with the Fal in bad weather. The river Fal is navigable at all states of the tide up to Malpas where it becomes a high water only creek up to Truro and other villages. There are numerous anchorages in all of the pools and side creeks of the Fal. There are also yacht harbours at St Mawes (visitor buoys), Mylor (small yacht club marina) Port Pendenis, (marina) Falmouth marina and Falmouth Haven (visitor buoys and summer pontoons just off the town quay).
Falmouth marina is just up the Penryn river and is the most convenient for a change-over port. It is a short taxi ride from the main-line train, has car parking and is all weather and all tide. It is close to a large supermarket for ships stores and is a gentle walk into the main town for the restaurants and pubs. Whilst relaxing in the area try anchoring in the St Just pool just north of St Mawes and then explore in the dinghy up the creek past the ancient church of St Just. There is lots more to read about at https://www.cornwalls.co.uk/falmouth/fal_river.htm or https://www.rya.org.uk/newsevents/e-newsletters/up-to-speed/Pages/up-the-river-fal-falmouth-harbour.aspx
We have often used Falmouth as a base or stopover, such as in 2018 on the way up to Scotland https://phoenixyachtclub.co.uk/cruising/summer-cruise/4007/ with another stop over in the Isles of Scilly